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Inventi Impact: Novel Excipients

Articles

  • Inventi:pne/61/13
    POTENTIAL USE OF POLYAMIDOAMINE DENDRIMER CONJUGATES WITH CYCLODEXTRINS AS NOVEL CARRIERS FOR SIRNA
    31-Dec-2012 Review 2013 : January - March
    Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi

    Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM)\r\nstarburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently,\r\nsmall interfering RNA (siRNA) complex with -CyD-containing polycations (CDP) having\r\nadamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment\r\nof solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical\r\napplications, including the interaction and intracellular delivery of DNA and RNA. The\r\npresent review will address the latest developments in dendrimer conjugates with\r\ncyclodextrins for siRNA delivery including the novel sustained release system.

    How to Cite this Article
    CC Compliant Citation: Hidetoshi Arima, Keiichi Motoyama,Taishi Higashi, Potential Use of Polyamidoamine Dendrimer Conjugates with\r\nCyclodextrins as Novel Carriers for siRNA, Pharmaceuticals 2012, 5, 61-78; doi:10.3390/ph5010061.
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